One of the most inspiring presentations for me at the Intervoice First World Hearing Voices Congress was that given by Professor Richard Bentall. His paper entitled ‘Why Relationships Matter: The Crucial Role of the Therapeutic Alliance in Helping People with Psychosis’ presented the results of research he had done into the therapeutic alliance and the results they had come up with.
The abstract to the paper talks of the history of therapy post-Second World War, immediately after the war the only therapy available was psychonalysis, considered to be costly and of limited efficacy, however during the post-war years there was a period of intense therapeutic innovation following two separate traditions: a technical tradition (behaviour modification, associated in the UK with Hans Eysenck and in the US with B F Skinner) which placed its faith in psychological theory, and an interpersonal tradition (associated with Carl Rogers) which emphasised the importance of therapeutic relationships. Prof. Bentall suggests that it is widely assumed that the technical approach triumphed, hence the popularity of CBT, it is cheap and gets results. But in this paper he asks whether such faith is justified, not that CBT treatments aren’t effective, but that research suggests that non-CBT therapies are too and that “Although further technical treatments may lead to improvements in psychological treatments for psychosis we neglect the interpersonal aspects of treatment at our peril”.
Sarting his paper Prof. Bentall gave a partial history of therapeutic treatments, arguing that the history is split between technique an empathy. He mentioned that clinical psychology was developed after the war in the hope that it would address the mountain of need in the asylums, in the US this was through the establishment of a PhD programme at the Boulder Conference of 1948, whilst in the same year clinical psychology training started in the UK with a 13 month training course at the Institute of Psychiatry.
Psychology was to be split between the technical approach pioneered by Skinner and Eysenck and the interpersonal approach of Carl Rogers. The early technical approach is exemplified by studies such ‘Extinction of psychotic speech in a patient, Helen, at the Saskatchewan Hospital in Canada’ (from Ayllon & Michael, 1959. The psychiatric nurse as a behavioral engineer. Journal of the Experimental Analysis of Behavior, 2, 323-334). Studies such as these showed that patients minds could be changed by behavioural modification. The high water mark came with the success of the token economy a reward system of systematic reinforcement that returned speech to previously mute patients. Although now considered unethical or too simplistic this was no mean feat and showed that behaviour modification could be very successful (‘The Token Economy’, Ayllon & Azrin, 1968)
Some psychologists, such as Carl Rogers, however, grew dissatisfied with the purely technical approach. Rogers rejected therapies such as psychoanalysis which he saw as too directive, he believed that patients had the capacity to heal themselves given the right circumstances and he believed that empathetic understanding, congruence and unconditional positive regard were the necessary and sufficient conditions for successful therapy. Rogers argued that research was necessary to prove his theories, both process research (what happened in the therapeutic session) and outcome research (the efficacy of the therapies). Thus he carried out one of the first RCTs of therapy with psychotic patients. The result was failure, both in terms of implementation of the project and the results (Rogers, Gendin,
Keisler & Traux, 1967). Although this may have been partly due to internal disagreements within the research group, it looked like the triumph of the behaviourists.
But others have rexamined these findings since, in 1977 a large scale controlled trial of the token economy took place. The token economy was compared to milieu therapy and TAU (treatment as usual). The discharge rates were 97%, 75% and 45% respectively (Paul & Lenz. 1977).This showed the efficacy of the token economy but it also showed that therapy was not without its merits. Other large scale tests have shown similar results (Dickerson et. al, 2005). Previously in 1966, Traux who had worked with but also disagreed with Rogers, showed that Rogers had unconsciously been using social reinforcement in his therapy. At the same time as the first large scale study of the token economy Hall, Baker et. al (1977) showed that social reinforcement – not the tokens themselves – was the successful ingredient in a token economy. The integration into an interpersonal, social community was a deciding factor. Empathic, genuine relationships are the more powerful reinforcers.
From as far back as 1936, Rosenzweig had suggested the Dodo conjecture (from Alice’s Adventures in Wonderland – ” All have won, all must have prizes”) that all therapies are equally efficacious. Again in 1977 Smith and Glass undertook a meta-analysis of psychotherapy outcomes that supported this conjecture, as have subsequent studies (Wampold, 2001). The effect size of psychotherapy versus treament as usual was .8, whilst the effect size between different psychotherpies was considered not significant.
So although the technical approach’s efficacy could not be denied, empathic genuine relationships definitely had an effect on the successful treatment of psychosis. Rogers may have had a point. It is therefore not unsurprising that CBT (Cognitive Behavioural Therapy) would ascend as a treatment. Bentall then turns to this treatment.
Prof. Bentall cites a series of papers cataloguing the successes of CBT in the treatment of psychosis; for psychotic patients who have not responded adequately to anti-psychotic medication (Cather et. al, 2004; Durham et al. 2003; Tarrier et al., Kuipers et al. 1998; Sensky et al. 2000; Turkington et al. 2003; Valmaggia et al. 2005); for remitted patients at risk of relapse (Bach & Hayes, 2002; Gaudiano et al, 2006; Gumley et al. 2003); acutely ill patients (Drury et al, 1999; Startup et al. 2004; Tarrier et al. 2004); and people thought to be at ultra high risk of an acute psychotic episode (Morrison et al. 2004). Bearing in mind the results of these studies, Bentall became involved in SoCRATES (the study of cognitive realignment therapy in early schizophrenia).
The SoCRATES study involved giving patients on 1st or 2nd admission for schizophrenia a randomised choice of CBT, counselling or routine care. They were given at 6 weekly assessments then followed up at 9 and 18 months. The results of the 18 month follow up showed a that both counselling and CBT had an effect over routine care however there was a highly significant centre affect between the three locations used in the study, Liverpool, Manchester and Nottingham. Some locations were significantly more effective than others. At the time this was not explicable.
There were other meta-analyses that suggested that CBT was superior to TAU in treatment of positive symptoms but had no effect on relapse (Pilling et al. 2002); that CBT was superior to TAU in the treatment of positive symptoms but there were lower effect sizes in larger trials (Tarrier & Wykes, 2004). In 2008, Wykes et al undertook a meta-analysis of 33 studies and confirmed the superiority of CBT over TAU for positive symptoms (33 studies, ES = .40), with some effect on negative symptoms, mood and functioning (13-23 studies, ES = 0.35 – 0.45). The most rigorous blinded studies showed ES = .22 for positive symptoms. So the evidence of the efficacy of CBT looked strong. But Prof. Bentall said there were still questions begging.
So he returned to the dod bird conjecture. Other papers have also shown the benefits of non-specific therapy. A 2000 paper by Sensky et al. suggested that befriending and CBT had similar effects during the treatment phase, only CBT was still more effective a year later. Papers in 1999 and 2000 by Tarrier et al. reported that CBT was superior to supportive counselling at a years follow up but there was no difference at 2 years, both were superior to TAU. Another paper by Tarrier from 2004 found CBT was superior to TAU but not supportive counselling.
Bentall suggested looking at non-specific factors that may account for this the effects of therapy. He pointed out two: the expectation of a postive outcome by the patient (Greenberg et al. 2006); and the therapeutic alliance – the affectional bond between the patient and therapist and their shared willingness to work towards mutually agreed goals (Horvath & Symonds, 1991; Martin et al. 2000).
Bentall was involved in a study with Dunn and Morrison (2006) looking at the therapeutic alliance, taking 29 patients receiving CBT for psychosis and looked at homework compliance. They found a significant relationship between the therapeutic alliance and homework compliance. Bentall returned to the Socrates study, he had asked for therapeutic alliance data to be taken at session 4 and session 10. There was a significant concurrence between therapists and patients as to the perception of the therapeutic relationship. But Bentall had no idea what the statistics meant. He turned to a colleague Day a specialist in statistics; conventional methods of analysing the therapeutic alliance are compromised by the possibility that the observed relationship between the alliance and outcome is inflated by unknown confounders.They developed a novel structural mean models (SMM) method of analysis method that eliminates this risk (Dunn & Bentall, 2007; Bentall et al. in press). The SMM analysis showed that the large centre effects in SoCRATES, the differences in outcome between Liverpool, Manchester and Nottingham, are entirely accounted for by the therapeutic alliance.
The therapeutic alliance has been shown to affect other outcomes in psychosis. Bentall argued that good collaborative relationships with patients are a universal good. However in conclusion Bentall pointed out the disparity in research. Research on psychological treatments for psychosis are at an early stage, in recent years there have been just 23 trials. In comparison between 2001-2003 there were 397 drug trials published in the five leading psychiatric journals. Bentall stated he remained positive about psychological interventions such as CBT and Commitment therapy but that the warm supportive relationships are therapeutic in themselves. Again he decalared them a universal good.